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Figure 3 | Molecular Pain

Figure 3

From: Network dynamics in nociceptive pathways assessed by the neuronal avalanche model

Figure 3

Effect of MT lesion on neuronal avalanche in ACC and S1. (A) A typical lesion site of the MT is shown in the left panel. The lesion sites in five different experiments were overlapped to show the overall distributions in the MT. (B) Colored lines indicate the distribution of avalanche size to probability in the ACC. The α values of pinch stimulation with an intact MT (red) and pinch stimulation with MT lesion (light green) are shown in the inset. (C) Colored lines indicate the distribution of avalanche size to probability in the S1. The α values of pinch stimulation with an intact MT (red) and pinch stimulation with MT lesion (blue) are shown in the inset. (D) The bar graphs show that pinch stimulation increased the α value compared with control in the ACC, but this effect was blocked by MT lesion. *p < 0.05, pinch stimulation vs. control under light anesthesia; # p < 0.05, pinch stimulation with an intact MT vs. pinch stimulation with MT lesion. (E) The bar graphs show that both brush and pinch stimulation increased the α value compared with control in the S1. The MT lesion did not influence this effect. The intact groups in D and E are the same data set of light anesthesia groups in the Figure 2C and 2D respectively. *p < 0.05, pinch or brush stimulation vs. control under light anesthesia. No significant difference was found between pinch or brush stimulation with an intact MT vs. pinch or brush stimulation with MT lesion.

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