Figure 3

AMG9678-induced decrease in T _b partially attenuates after repeat dosing in rats. AMG9678 was administered (p.o.) each day at 9:00 am for 4 days as indicated by an arrow. T_b data was collected every hour for 80 h and are presented as mean ± S.E.M. A) AMG9678 at 30 mg/kg produced a significant decrease of T_b by 0.62°C at 5 h (t ₁₄ = 4.27, p < 0.001), 0.47°C at 26 h ( t ₁₄ = 4.95, p < 0.001), 0.51°C at 52 h ( t ₁₄ = 5.01, p < 0.0001), and 0.38°C at 75 h ( t ₁₄ = 2.68, p < 0.01), respectively. The decrease in T_b lasted for 7 h post 1^st dosing, 5 h post 2^nd dosing, 5 h post 3^rd dosing and 6 h post 4^th dosing, respectively. B. AMG9678-induced decrease in T_b reduced on day 2–4 compared to day 1. Bars represent mean ± S.E.M. of ΔT of average 1–7 h post dosing on days 1–4.