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Figure 2 | Molecular Pain

Figure 2

From: Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn

Figure 2

A. Pretreatment with Sap or SSP-Sap made no difference in time spent on an accelerating rotarod before falling off. B. Rats pretreated with Sap developed a profound mechanical allodynia following carrageenan as shown by their 50% probability withdrawal threshold to von Frey filaments. Animals pretreated with SSP-Sap also developed hyperalgesia, but thresholds were elevated compared to SAP pretreated animals at all timepoints except at 2 h post-carrageenan. C. Area under the curve for the two treatments indicates that SSP-Sap reduced allodynia integrated over the entire time period. ** = p ≤ 0.001

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Molecular Pain

ISSN: 1744-8069

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