Figure 8

Possible mechanisms for the inhibition by calcitonin of the abnormal expression of sodium channels. (a) The action of calcitonin under normal conditions. Calcitonin-induced signal via CTR are silent under normal condition. (b) Nerve injury not only induces the abnormal expression of Na⁺ channels but also could trigger the activation of the silent signal to a functional one. Calcitonin may exert anti-hyperalgesic effects following the inhibition of the abnormal expression of Na⁺ channels via these functional signals.