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Figure 8 | Molecular Pain

Figure 8

From: Activation of extracellular signal-regulated protein kinase 5 is essential for cystitis- and nerve growth factor-induced calcitonin gene-related peptide expression in sensory neurons

Figure 8

Schematic diagram illustrates the putative mechanism for NGF signal transduction that mediates the interaction of the inflamed urinary bladder and bladder sensory neurons in the DRG. Cystitis- induced NGF expression in the urinary bladder binds to TrkA and activates ERK5 and CREB in DRG via retrograde transport. The NGF-ERK5-CREB axis leads to CGRP up-regulation in bladder afferent neurons (A). The NGF-induced Akt activation (B) may contribute to TRPV1 sensitization [61] but not the CGRP up-regulation in the DRG. In addition to regulating CGRP expression, activation of CREB in bladder afferent neurons may also control gene expression of other neuropeptides (NPP) (C). These multi-branches of signaling pathways triggered by NGF may together mediate cystitis-induced bladder hyperactivity.

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Molecular Pain

ISSN: 1744-8069

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