Skip to main content
Figure 4 | Molecular Pain

Figure 4

From: Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Figure 4

Resveratrol suppresses eIF4F complex formation in sensory neurons. TG neurons were treated with resveratrol (10, 30 and 100 μM) for 1 h. A) Western blot for eIF4G, 4EBP and eIF4E from trigeminal neurons co-precipitated using 7-methyl-GTP conjugated beads. B) Resveratrol induces a significant increase in 4EBP (negative regulator of translation) association with the cap-binding protein eIF4E in a dose-dependent manner. C) Resveratrol induces a significant decrease in eIF4G association with the cap-binding protein eIF4E (a component of eIF4F complex) in a dose-dependent manner.

Back to article page

Molecular Pain

ISSN: 1744-8069

Contact us