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Table 2 Sirt1 activators fail to recapitulate resveratrol-induced effects on TG neurons.

From: Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Antibody

Vehicle

CAY10602 20 μM

CAY10602 60 μM

p-AMPK/AMPK

100 ± 13.6

95.0 ± 14.4

107.3 ± 16.6

p-ERK/ERK

100 ± 6.50

117.2 ± 5.91

126.4 ± 3.32 *

p-eIF4E/eIF4E

100 ± 13.0

105.9 ± 17.1

102.0 ± 17.0

p-AKT/AKT

100 ± 11.8

105.8 ± 5.0

107.2 ± 7.5

p-mTOR/mTOR

100 ± 8.8

103.8 ± 17.0

125.7 ± 18.5

p-TSC2/TSC2

100 ± 3.3

97.8 ± 6.8

115.1 ± 5.2

p-4EBP/4EBP

100 ± 8.3

126.2 ± 11.1

122.9 ± 8.5

p-eIF4G/eIF4G

100 ± 14.1

76.2 ± 13.8

109.0 ± 16.7

p-rS6p/rS6p

100 ± 12.5

120.3 ± 6.8

134.0 ± 10.5

  1. TG neuronal cultures were treated with the sirt1 activator, CAY10602 (20 and 60 μM) for 1 h. The phosphorylated levels of AMPK, ERK, eIF4E, AKT, mTOR, 4EBP and rS6p were not changed by CAY10602
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Molecular Pain

ISSN: 1744-8069

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