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Table 2 Sirt1 activators fail to recapitulate resveratrol-induced effects on TG neurons.

From: Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain

Antibody Vehicle CAY10602 20 μM CAY10602 60 μM
p-AMPK/AMPK 100 ± 13.6 95.0 ± 14.4 107.3 ± 16.6
p-ERK/ERK 100 ± 6.50 117.2 ± 5.91 126.4 ± 3.32 *
p-eIF4E/eIF4E 100 ± 13.0 105.9 ± 17.1 102.0 ± 17.0
p-AKT/AKT 100 ± 11.8 105.8 ± 5.0 107.2 ± 7.5
p-mTOR/mTOR 100 ± 8.8 103.8 ± 17.0 125.7 ± 18.5
p-TSC2/TSC2 100 ± 3.3 97.8 ± 6.8 115.1 ± 5.2
p-4EBP/4EBP 100 ± 8.3 126.2 ± 11.1 122.9 ± 8.5
p-eIF4G/eIF4G 100 ± 14.1 76.2 ± 13.8 109.0 ± 16.7
p-rS6p/rS6p 100 ± 12.5 120.3 ± 6.8 134.0 ± 10.5
  1. TG neuronal cultures were treated with the sirt1 activator, CAY10602 (20 and 60 μM) for 1 h. The phosphorylated levels of AMPK, ERK, eIF4E, AKT, mTOR, 4EBP and rS6p were not changed by CAY10602