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Figure 4 | Molecular Pain

Figure 4

From: CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy

Figure 4

TAT-CBD3 and TAT-CBD3A6K peptides reduce the excitability of nociceptive dorsal root ganglia (DRG) neurons. Current clamp recordings were performed on small-to-medium (>30 μm– >40 μm) diameter lumbar 4–5 DRG neurons from d4T-treated rats. Firing of 4–6 action potentials (APs) was elicited by a 1 second depolarizing current injection (ranging from 0.1 to 0.4 nA depending on the cell) every 30 seconds (A, D). Representative recordings demonstrating that application of 10 μM CBD3 and CBD3A6K reduces the number of elicited action potentials (B, E). Group data showing that TAT-CBD3 (C) and TAT-CBD3A6K (E) caused a significant reduction in DRG action potential firing (*, p <0.05 versus control, Student’s t-test; n = 8 each)

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Molecular Pain

ISSN: 1744-8069

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