Reduction in postherpetic neuralgia in Y1472F-KI mice. (A) Time-course analysis of mechanical allodynia after HSV-1 inoculation. Wild-type and Y1472F (YF) mice were inoculated with HSV-1 on lacerated shin skin. At various times post inoculation, the plantar was stimulated by use of a von Frey filament (1.6 mN), and the response was assessed as pain-related score. Data are presented as the mean ± SEM (n = 19 and 17 in wild-type and Y1472F-KI mice, respectively). *P < 0.05 vs. wild-type mice (Mann-Whitney's U-test). (B) Comparison of the intensity of allodynia between wild-type and Y1472F-KI mice. Mice were categorized into 3 groups according to the pain-related score: low (< 0.5), moderate (0.5–0.9), and high (≥ 1.0). Data are presented as percentage of total mice tested, and the number of mice in each pain category is shown on the bars.