Figure 3From: Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors Decreased locomotor activity in HbSS mice in the open field test. The open field test was used to measure locomotor activity and anxiety. Animal movement over a 20-minute period was recorded. (A) HbSS traveled 706 ± 37 cm (n = 9) compared to HbAA controls that traveled 2081 ± 123 cm (n = 10), a 2.9-fold decrease (**P <0.01). (B) Time spent in the center zone averaged 191 ± 26 sec compared to HbAA controls that traveled 88 ± 23 sec. (C) Both genotypes exhibited a similar frequency of entries into the center zone. Genotypes were compared using a two-way ANOVA with Bonferroni’s post-hoc analysis (A) and student’s t-tests (B, C). Error bars indicate S.E.M.Back to article page