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Figure 2 | Molecular Pain

Figure 2

From: Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis

Figure 2

a. Left: Representative tracing of action potentials displayed by DRG neurons in culture after 48 hours of exposure to TGFβ1, in response to current injections of 1x or 2x rheobase. Middle: Bar graph showing the average number of action potentials evoked by 2x rheobase current injection after 48 hours of culture with TGFβ1 or control. Right:.Action potential frequency of DRG neurons in cultures increases with increasing duration of exposure to TGFβ1 (P =0.02 by ANOVA). b. Bar graphs showing electrophysiological changes in cultured DRG neurons after 48 hours of exposure to TGFβ1. Left: Resting membrane potential (n = 19 in each group); Middle: Voltage threshold for triggering an action potential (n = 19 in each group); Right: Rheobase (current required to trigger an action potential) (n = 20 in each group). *P <0.05. **P <0.01.

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Molecular Pain

ISSN: 1744-8069

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