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Figure 8 | Molecular Pain

Figure 8

From: Expression of the transient receptor potential channels TRPV1, TRPA1 and TRPM8 in mouse trigeminal primary afferent neurons innervating the dura

Figure 8

Overlay of the cumulative distributions of the TRPV1+ , TRPA1+ and TRPM8-expressing neurons in the V 1 /V 2 divisions of the TG. Cumulative distribution of the cross-sectional areas of the total TG neurons in the V1/V2 divisions (dashed gray line, the same neurons as in Figure 1 F), the TRPV1+ neurons (solid black line, the same neurons as in Figure 5 E), the TRPA1+ neurons (red line, the same neurons as in Figure 6 E), and the TRPM8-expressing neurons (dashed green line, the same neurons as in Figure 7 E). A Kruskal-Wallis ANOVA with Dunn’s post hoc test reveals that the sizes of TRPV1+ neurons are the smallest of the three populations of TG neurons (p < 0.001 and p < 0.05 compared with the TRPA1+ and EGFPf+ groups, respectively). In contrast, the sizes of TRPA1+ neurons are significantly larger than those of the TRPV1+ and TRPM8-expressing neurons (p < 0.001 and p < 0.05, respectively).

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