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Figure 6 | Molecular Pain

Figure 6

From: NAAG peptidase inhibition in the periaqueductal gray and rostral ventromedial medulla reduces flinching in the formalin model of inflammation

Figure 6

ZJ43 microinjection into the RVM. Formalin injection into the dorsal surface of the left rat hind-paw induced two phases of hindpaw flinching in the saline injected control rats (n = 7). a. Microinjection of 150 μg of ZJ43 (n = 7) into the contralateral RVM reduced both of phases of the pain response observed after the formalin injection. Pre-treatment with 1 mg/kg (i.p.) of the group II mGluR antagonist LY341495 (n = 10) blocked the effect of ZJ43 in the RVM. b. Sum of flinches following microinjection of saline, ZJ43 or ZJ43 with LY341495 into the RVM. Phase one data are the sum of flinches for the first 10 min. Phase two data are the sums of flinches from 10–60 min. Data are calculated from Figure 6a.

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Molecular Pain

ISSN: 1744-8069

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