Figure 5

Reversal of the oxaliplatin-induced cold hyperalgesia in rats by Ca²⁺ and Na⁺ channel blockers. Oxaliplatin (4 mg/kg) was administered i.p. on days 1 and 2. Nifedipine (A : 10 and 30 mg/kg), diltiazem (B: 10 and 30 mg/kg), ethosuximide (C: 100 and 300 mg/kg) or mexiletine (D: 3-30 mg/kg) was orally co-administered with oxaliplatin. Acetone test was performed on days 0, 3, 5, 8 and 15. Values are expressed as the mean ± SEM of 6-10 animals. ††p < 0.01 compared with vehicle group, *p < 0.05, **p < 0.01 compared with oxaliplatin group.