Figure 3

Effect of AM1710 on chemotherapy-induced mechanical and cold allodynia. AM1710 suppressed both mechanical (A, B) and cold (C, D) allodynia evoked by cisplatin (A, C) or paclitaxel (B, D) treatment. Data are expressed as mean ± SEM (n = 5-13 per group). ^*** P < 0.001, ^** P < 0.01, ^* P < 0.05 vs. DMSO vehicle, One-way ANOVA followed by Dunnett post hoc test. ^xxx P < 0.001 vs. AM1710 (1 and 5 mg/kg i.p.), One-way ANOVA followed by Bonferroni post hoc test. ⁺ P < 0.05 vs. DMSO vehicle, planned comparison t-test. ^$$ P < 0.01, ^$ P < 0.05 vs. pre-drug baseline (−60 min), paired t-test. ^### P < 0.001 vs. pre-cisplatin/paclitaxel baseline (BL), repeated measures ANOVA.