Figure 3
From: Sensory discrimination between innocuous and noxious cold by TRPM8-expressing DRG neurons of rats
Inhibition by cooling temperatures of voltage-activated inward currents in TTXs/TRPM8 and TTXr/TRPM8 DRG neurons. A) Sample traces of voltage-activated inward currents recorded from a TTXs/TRPM8 cell at 24°C (left), in the presence of 500 nM TTX (middle), and at 10°C (Right). B) Experiment was similar to (A) except the recorded cell was a TTXr/TRPM8 neuron. C) Summary of peak amplitude of the inward currents recorded at 24°C and 10°C. Left panel: TTXs/TRPM8 cells. Right panel: TTXr/TRPM8 cells. D) Remaining inward currents at 10°C. The remaining inward currents at 10°C are expressed as the percentage of peak inward currents at 24°C. Data represent mean ± SEM, *P < 0.05.