Figure 2
From: 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1
Abilities of fragrance chemicals to activate hTRPM8 or hTRPA1. (A, C) Effects of 1,8-cineole on fura-2 ratio in HEK293T cells expressing hTRPM8 (n = 32) (A) or hTRPA1 (n = 41) (C). (B, D) Comparison of the effects of fragrance chemicals (1 mM) on hTRPM8 (n = 16–80) (B) or hTRPA1 (n = 30–90) (D). Fura-2 ratio increases by each chemical were normalized to the fura-2 ratio increases by 1 mM menthol. (E) The Ratio of hTRPM8-activating ability versus hTRPA1-activating ability by dividing the values in (B) by the values in (D).