Figure 5
From: 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1
Effects of 1,8- or 1,4-cineole on HEK293T cells expressing hTRPM8 or hTRPA1. (A, B) 1,8-cineole (5 mM) activated hTRPM8 (A) with an outwardly rectifying current–voltage relationship, but not hTRPA1 (B). (C, D) 1,4-cineole activated both hTRPM8 and hTRPA1 with an outwardly rectifying current–voltage relationship. The insets (A, C and D) indicate the current–voltage relationship at the point indicated by * in the left trace.