Figure 4
Numbers of infiltrating leukocytes (CD45hi ) in lumbar spinal cord following L5Tx in WT, CD4KO, and CD40KO mice. Total mononuclear cells collected as described in Figure 2 were analyzed for their content of infiltrating leukocytes. The temporal changes of the numbers of lumbar spinal cord infiltrating leukocytes in WT (A, n = 5–8), CD4 KO (B, n = 4) and CD40 KO (C, n = 4) mice are shown here (mean ± SEM). One-way ANOVA was performed to examine the basal level genotypic differences among naïve mice and no significant differences were found. Two-way ANOVA for data sets in each graph were performed. # indicates significant differences between the indicated group and all other groups within the same treatment group (including the corresponding Day 0 group). An additional significant result from statistical comparison is also shown within the graph. “Tx” = L5Tx, “Sh” = sham operation, “ipsi” = ipsilateral side, and “contra” = contralateral side. For naïve mice, “ipsi” = left and “contra” = right.