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Figure 1 | Molecular Pain

Figure 1

From: Upregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation

Figure 1

NMD enhanced CBS expression in rats with visceral hypersensitivity. (A-D). Time course of changes in distention threshold after NMD. NMD significantly reduced distention threshold when compared with age-matched controls at the 7 weeks (A, n=8 rats for each group, **P<0.01), 9 weeks (B, n=8 for each group, **P<0.01), 12 weeks (C, n=8 rats for each group, *P<0.05). NMD did not significantly alter distention threshold when compared with age-matched controls at the 15 weeks (D, n=8 rats for each group). (E-H). Time course of changes in CBS expression after NMD. NMD significantly upregulated expression of CBS and increased AWR scores when compared with age-matched controls at 7 weeks (E, n=3 rats for each group; *P< 0.05), 9 weeks (F, n=3 rats for each group, *P<0.05), and 12 weeks (G, n=3 rats for each group; *P<0.05). NMD did not significantly alter CBS expression when compared with age-matched controls at 15 weeks (H, n=3 rats for each group). Actin was used as an internal control for each group.

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Molecular Pain

ISSN: 1744-8069

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