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Figure 2 | Molecular Pain

Figure 2

From: Upregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation

Figure 2

CBS inhibitor AOAA attenuated AWR scores in NMD rats. (A) CBS inhibitor abolished visceral hyperalgesia induced by NMD in a dose dependent manner. The maximal effect was at 10 mg/kg body weight (i.p.) in this study. n=8 rats for each dose group; *P<0.05. (B) CBS inhibitor mitigated visceral hyperalgesia induced by NMD time-dependently. AOAA-induced antinociceptive effect lasted for about 60 minutes in both 10 and 20 mg/kg body weight. n=8 rats for each group; *P<0.05. (C) AOAA (10 mg/kg body weight) had no effect on AWR scores of age-matched healthy control rats (n=8).

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Molecular Pain

ISSN: 1744-8069

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