Functional annotation data derived from DAVID algorithm (Part One). Graph derived from the functional annotation chart that shows all cellular functions that include ApoE as a component (ApoE is assigned to that functional annotation) given as the number of proteins identified by MUDPIT with that specified functional annotation. The numbers indicate the number of proteins detected in the proteomic study that are clustered in that functional annotation (all of which include ApoE) following SNL (blue) or SNL with metformin (red) treatment. The graph includes functional annotations where the protein number in injured sciatic nerves (blue) and in injured nerves following metformin treatment (red) is not different. Hence, these functional annotations are not modulated by metformin and appear to be associated with an injury response that is resistant to metformin treatment.