Functional annotation data derived from DAVID algorithm (Part Two). Graph derived from the functional annotation chart that shows all cellular functions that include ApoE as a component (ApoE is assigned to that functional annotation) given as the number of proteins identified by MUDPIT with that specified functional annotation. The numbers indicate the number of proteins detected in the proteomic study that are clustered in that functional annotation (all of which include ApoE) following SNL (blue) or SNL with metformin (red) treatment. The graph indicates number of proteins for functional annotations containing ApoE that are unique to injured nerves (blue) and are not apparent with metformin treatment (lack of red bars). Moreover, metformin treatment induces the expression of number of proteins that belong to functional annotations containing ApoE that are not observed with nerve injury. These functional annotations are linked to enhance regeneration and repair of the peripheral nervous system (red) and these functional annotation sets are absent in SNL rats (lack of blue bars).