Figure 5

AMPA- but not NMDA-induced current amplitude increase by IL-1β disappeared in the presence of minocycline. (A, B) Recordings of AMPA (A) or NMDA (B)-induced currents in Krebs solution without drugs (left), with minocycline (20 μM) alone (middle) and both minocycline and IL-1β (right). In each of (A) and (B), all recordings were obtained from the same neuron. (C) Bar graphs showing the averaged peak amplitudes of AMPA (left, n=6)- and NMDA (right, n=5)-induced currents in the presence of IL-1β (gray bar), relative to those in the absence of IL-1β (black bar), in Krebs solution containing minocycline. Note that minocycline itself inhibited NMDA- but not AMPA-induced currents (compared to control, open bar).