Figure 8

PME but not resveratrol inhibits CAP-induced pain behavior. PME (300 μM, 50 μl) or resveratrol (RES, 300 μM, 50 μl) was pre-treated subcutaneously 5 min before capsaicin (CAP, 0.05% in 50 μl saline with 0.5% tween20) or VEH injection. A, C: Time course of the number of paw flinches (A) or duration of paw licks (C) induced by capsaicin or VEH after PME or resveratrol pretreatment, respectively. The number of flinches and duration of licks were counted per 5 min interval in the initial 30 min period after capsaicin or VEH injection. * p < 0.05, ** p < 0.01, versus VEH + CAP (one-way ANOVA followed by Fisher’s PLSD); ## p < 0.01, versus VEH + CAP group (two-way repeated ANOVA followed by Fisher’s PLSD). B, D: Cumulative number of paw flinches (B) or duration of paw licks (D) in the initial 30 min period after capsaicin-injection. $$ p < 0.01, versus VEH + CAP (one way ANOVA followed by Fisher’s PLSD). Numbers in parentheses indicate number of rats used in each group.