Figure 2
Drug effects on audible vocalizations. Effects of intra-BLA infusion of a selective 5-HT2CR antagonist (SB242084, 10 μM), systemic administration of an SSRI (fluvoxamine, 30 mg/kg, i.p) and combined administration of SB242084 and fluvoxamine on audible vocalizations evoked by innocuous (300 g/30 mm2, A,B) and noxious (1200 g/30 mm2, C,D) stimulation of the knee joint in sham control (A,C) and arthritic (B,D) rats. The drug combination had significant inhibitory effects in the arthritis pain model. *,*** P < 0.05, 0.001, compared to vehicle control (first bar in each histogram), one-way ANOVA followed by Dunnett’s multiple comparison tests. Bar histograms show means ± SEM of the total duration vocalizations over a 1 min period following the onset of the mechanical stimulus.