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Figure 4 | Molecular Pain

Figure 4

From: Brain-derived neurotrophic factor enhances the excitability of small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone following masseter muscle inflammation

Figure 4

Double-labeling of dissociated TRG neurons recorded under current-clamp and BDNF responsiveness in naïve and inflamed rats. Acutely dissociated TRG neurons observed under phase contrast microscopy ( A ), identified by FG-injection in the MM ( B ) and by MB injection into the Vi/Vc region in the same field (C). Bar = 20 μm. Arrow heads denote the target cell following FG/MB injection. D : Size distribution of dissociated FG/MB-labeled small-diameter TRG neurons recorded in both naïve and inflamed rats. BDNF responsiveness was determined by changes in the membrane potentials (>1 mV). E : Percentage of BDNF responsiveness in FG/MB-labeled small-diameter TRG neurons.

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