Activation of mammalian target of rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator

Table 4 Effect of rapamycin (post-treatment) on mechanical and thermal hypersensitivity induced by BmK I

	Paw withdrawal mechanical threshold (g)				Paw withdrawal thermal latency (s)
	Vehicle	Rapa	Rapa	Rapa	Vehicle	Rapa	Rapa	Rapa
	Vehicle	20 μM	200 μM	2 mM	Vehicle	20 μM	200 μM	2 mM
Ipsilateral
Base line	26.00 ± 0.00	26.00 ± 0.00	24.63 ± 1.38	26.00 ± 0.00	12.59 ± 0.19	13.28 ± 0.25	13.30 ± 0.37	12.94 ± 0.27
4 h	1.80 ± 0.21	4.00 ± 0.89	4.00 ± 0.18 *	4.93 ± 0.56 **	5.98 ± 0.36	9.21 ± 0.60 ***	9.83 ± 0.39 ***	8.86 ± 0.28 ***
8 h	2.13 ± 0.33	5.25 ± 1.08 **	6.00 ± 0.35 ***	6.75 ± 0.62 ***	6.36 ± 0.31	9.61 ± 0.41 ***	9.55 ± 0.22 ***	9.38 ± 0.12 ***
Contralateral
Base line	26.00 ± 0.00	26.00 ± 0.00	24.63 ± 1.38	26.00 ± 0.00	12.43 ± 0.26	12.94 ± 0.23	12.36 ± 0.16	12.54 ± 0.24
4 h	2.50 ± 0.27	9.13 ± 0.83 ***	8.88 ± 0.74 ***	8.63 ± 0.81 ***	12.04 ± 0.42	12.94 ± 0.21	12.21 ± 0.34	12.03 ± 0.23
8 h	2.75 ± 0.40	10.00 ± 1.77 ***	10.38 ± 1.23 ***	8.38 ± 0.87 ***	12.11 ± 0.25	13.1 ± 0.35	13 ± 0.36	12.13 ± 0.21

Note: *p<0.05, **p<0.01, ***p<0.001, compared with relevant vehicle groups. Two-way ANOVA followed by a Bonferroni's post hoc test.

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