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Table 1 Inhibition parameters of the three ω-conotoxins on I Ca recorded from isolated DRG neurons

From: Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration

Peptide

CVID

CVIE

CVIF

Maximal Inhibition of ICa (% of total)

52 ± 2

45 ± 4

47 ± 6

Log [IC50]

-7.12 ± 0.04

-8.22 ± 0.03

-7.85 ± 0.03

Recovery from block (% of inhibition, 10 min)

-1 ± 5

0 ± 3

24 ± 10

Peak inhibition vs. recovery at 10 min (t-test)

P = 0.3

P = 0.2

P < 0.05

  1. No significant difference was observed in the maximal inhibition by any of the peptides (P = 0.52 with one-way ANOVA). Differences between the concentration-responses of the three peptides were tested using two-way ANOVA (P < 0.0001) and followed up with Bonferroni’s post-test. The IC50 of CVID was significantly less than that of CVIE and CVIF (P < 0.001 for both comparisons), but no difference was found between CVIE and CVIF (P > 0.05). Hill slopes of all three concentration-response relationships were not significantly different from 1. Recovery from block was tested using paired t-test, and significant recovery was observed only from inhibition by CVIF (P < 0.05).
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Molecular Pain

ISSN: 1744-8069

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