Figure 3

Day 14: Distribution of inflammatory mediator expression in each tissue as ranked by FC. (A) The distribution profile of mediator expression in each tissue at day 14 in the MIA model. The data points show the mean FC for each individual transcript. These values are ranked in order, starting from those most down-regulated (compared to control), to those most up-regulated. Adjacent data points in different tissues do not necessarily correspond to the same gene. The blue shaded box represents an area of +/-2 ≤ FC. X-axis is on a log2 scale. Data are displayed as the mean FC, FC = MIA/Control, n = 92. (B) The percentage of genes > 2 FC up-regulated in the each tissue. As shown, the greatest percentage of genes was up-regulated in the cartilage (24.7%) as compared to the subchondral bone (9.7%) and fat pad (10.8%).