Figure 1

Schematic of aPKC isoforms and pseudosubstrate inhibitor ZIP: A) The figure shows the protein structure for PKCλ and PKCζ/PKMζ proteins including alignment of pseudosubstrate regions for both genes and conserved phosphorylation sites. Note that PKMζ is the only aPKC lacking a regulatory region. B) Shows the alignment of ZIP and scrambled control peptide seuqneces agaonist the position-specific scoring matrix logo of PKCζ showing some conservation of critical residues [39].