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Archived Comments for: Analgesic tolerance of opioid agonists in mutant mu-opioid receptors expressed in sensory neurons following intrathecal plasmid gene delivery

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  1. An important reference on the identification of specific PKC phosphorylation site in mu-opioid receptors.

    Li-Yen Huang, University of Texas Medical Branch

    6 January 2014

    Feng et al (2011)* showed that S363 is a major PKC phosphorylation site on mu-opioid receptors (μ-MORs).  The PKC-mediated phosphorylation of the site interrupts receptor-G protein coupling, thus promoting the desensitization of μ-MORs

    *Feng B, Li Z Wang JB: Protein kinase C-mediated phosphorylation of the mu-opioid receptor and its effects on receptor signaling. Molecular pharmacology 2011, 79: 768-775.

    Competing interests

    None declared