Figure 2

Low levels of paclitaxel are found in the CSF and spinal dorsal horn after paclitaxel injection and intrathecal injection of paclitaxel induces acute pain in rats. (A) and (B): Concentrations of paclitaxel in the CSF (A) and spinal dorsal horn (B) in rats at 2, 4, and 24 h after i.v. injection of paclitaxel (2 mg/kg) are shown. Number of animals included in each group for the analysis is shown in each bar. **P < 0.01; ***P < 0.001. (C): Mechanical thresholds of withdrawal responses in rats before (baseline) and different time points after intrathecal injection of paclitaxel at 0.2 ng, 2 ng, and 20 ng, or vehicle in different groups are plotted. Comparisons between baseline and at each time point are indicated with ^ for rats receiving 2 ng paclitaxel, and with + for rats receiving 20 ng paclitaxel. Comparisons at each time point between rats receiving vehicle, and rats receiving 2 ng paclitaxel are labeled with *, or rats receiving 20 ng paclitaxel are indicated with #. One symbol: P < 0.05; Two symbols: P < 0.01.