Figure 3

TLR4 in the spinal dorsal horn and dorsal root ganglions are activated following intravenous or intrathecal injection of paclitaxel. Expression of phosphorylated TLR4 (p-TLR4) and total TLR4 (t-TLR4) in the spinal dorsal horn and dorsal root ganglions of L4-L5 spinal segments 4 hrs after i.v. injection of taxol (2 mg/kg) or vehicle are shown in (A). Expression of phosphorylated TLR4 (p-TLR4) and total TLR4 (t-TLR4) in the spinal dorsal horn and dorsal root ganglions of L4-L5 spinal segments 1 hr after intrathecal injection of taxol (20 ng) or vehicle are shown in (B). Number of animals included in each group for the analysis is indicated in each bar. *P < 0.05; **P < 0.01; ***P < 0.001.