Figure 4From: The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury The expression of phosphorylated CREB (pCREB) in the dorsal horn is attenuated in BLT1KO mice. Representative diaminobenzidine-stained images showing pCREB-positive neurons in sections of the ipsilateral (A) and contralateral (B) dorsal horn of the lumbar spinal cord before or 20 min after a peripheral formalin injection (magnification, 100×). Arrowheads indicate pCREB-positive neurons. The number of pCREB-positive neurons in the ipsilateral (C) and contralateral (D) dorsal horn of the lumbar spinal cord prior to or 20 min after formalin injections. (**** p < 0.0001 vs. BLT1WT mice, n = 6, two-way ANOVA with Bonferroni post hoc test).Back to article page