Figure 5

Antihyperalgesic effect of compounds against persistent inflammatory pain. Time course and dose-dependent antihyperalgesic effect of (A) suramin (1.0-10.0 μg/i.t.), (B) gossypetin (1.0-10.0 μg/i.t.) and (C) oxytetracycline (10.0 μg/i.t.) on mechanical hyperalgesia of mice injected with CFA. Each circle represents the mean ± S.E.M. (n=6-7) and is representative of 2 independent sets of experiments. Statistical analyses were performed by two-way ANOVA followed by a Tukey’s test. The dashed line and number symbol indicate the range of data points where injured animals differed from the group injected intraplantarly with PBS (P<0.001).