Figure 4
Effects of ZBD-2 on protein expression in the BLA. (A) Representative results of Western blot analysis in the BLA on the Day 21 after hindpaw CFA-injection. (B) ZBD-2 (0.15 and 1.5 mg/kg) for one week slightly decreased the levels of NR2A-containing NMDARs. (C) ZBD-2 (1.5 mg/kg) reversed the upregulation of NR2B-containing NMDARs. (D-E) ZBD-2 (0.15 and 1.5 mg/kg) reversed the upregulation of GluR1 and CaMKII-α. (F) Representative results of Western blot analysis for GABAA-α2 and GAD67. (G and H) Levels of GABAA-α2 and GAD67 were not altered in groups. n = 6 in each group, *p < 0.05, **p < 0.01 compared to the control group; # p < 0.05, ## p < 0.01 compared to the CFA+ saline group.