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Figure 5 | Molecular Pain

Figure 5

From: Anxiolytic-like effects of translocator protein (TSPO) ligand ZBD-2 in an animal model of chronic pain

Figure 5

Effects of ZBD-2 on mEPSC in the BLA. (A) Representative mEPSCs recorded in pyramidal neurons of BLA at a holding potential of-70 mV. (B) Cumulative frequency and amplitude histogram of the mEPSCs from the slices in each group. (C) Summery of mEPSCs frequency (left) and amplitude (right) in control (n = 11 slices/4 mice), CFA-vehicle (n = 10 slices/4 mice), CFA-ZBD-2 (n = 12 slices/4 mice) treated mice. ZBD-2 (1.5 mg/kg) for one week reversed the increases of mEPSCs frequency and amplitude in CFA-treated mice. *p < 0.05 compared to the control group; # p < 0.05 compared to the CFA+ saline group.

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Molecular Pain

ISSN: 1744-8069

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