Figure 4
From: MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway
Change of MeCP2 transcript, miR-132 and p-CREB after SNI. A, MeCP2 transcript did not change significantly after SNI. B, miR-132 was downregulated by 3d to 7d after SNI. RNAs were collected from lumbar spinal cord L4-L6 lysates of WT mice. Levels of MeCP2 transcript and miR-132 were analyzed by qPCR. C, p-CREB(Ser133) was elevated by 3 days after SNI and then fell off. D, Relative protein level of p-CREB expression in spinal cord. Bars are relative protein level to control without SNI. Error bars are SEM. *p < 0.05 , **p < 0.01 (t test).