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Fig. 8 | Molecular Pain

Fig. 8

From: Upregulation of T-type Ca2+ channels in long-term diabetes determines increased excitability of a specific type of capsaicin-insensitive DRG neurons

Fig. 8

TTX-sensitive and TTX-resistant Na+ currents do not contribute to neuronal excitability in the caps−lpH+ neurons. a Steady-state activation of TTX-sensitive, TTX-S, component of Na+ current. Insert: representative traces of TTX-S Na+ current b A part of a low voltage region from A is presented in a larger scale demonstrating negligible values of TTX-S current at depolarization steps in a range of −70 - -50 mV (n = 9 from three rats). c Steady-state activation curve of TTX-resistant, TTX-R, component of Na+ current demonstrating its activation threshold at −35 mV (n = 9 from three rats). Insert: representative traces of TTX-R Na+ current. Altogether these results demonstrate a lack of low-threshold TTX-R current and substantially lower density of TTX-S current compared to T-type current [39] at depolarization steps up to -40 mV

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Molecular Pain

ISSN: 1744-8069

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