Figure 5

The postnatal change of EGFP-positive dural afferent fibers in TRPM8 ^EGFPf/+ and TRPM8 ^EGFPf/EGFPf mice. a EGFP-positive fiber densities in the dura of P2 and adult TRPM8 ^EGFPf/+ (TRPM8-Hz, same data as in 2B EGFP groups) and TRPM8 ^EGFPf/EGFPf mice (TRPM8-Hm, n = 8 and 6 mice in P2 and adult groups, respectively). **p < 0.01, ***p < 0.001, two-way ANOVA with post hoc Bonferroni test. b Percentage of adult versus P2 EGFP-positive axon densities in TRPM8-Hz and TRPM8-Hm mice (same mice as in a). c The average number of branch points per EGFP-positive fiber in the dura of P2 and adult TRPM8-Hm (same mice as in a) and TRPM8-Hz mice (same data as in Figure 4d EGFP groups). *p < 0.05, **p < 0.01, two-way ANOVA with post hoc Bonferroni test, compared with the corresponding P2 groups. There is no difference between TRPM8-Hz and TRPM8-Hm groups at P2 (p = 0.53) or adulthood (p = 1.5). d Percentage of adult versus P2 branch points per EGFP-positive fiber in TRPM8-Hz and TRPM8-Hm mice (same mice as in c).