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Figure 3 | Molecular Pain

Figure 3

From: Distribution of raphespinal fibers in the mouse spinal cord

Figure 3

Termination pattern of BDA labeled fibers arising from GiV. ac An injection site in GiV (red dashed circle) which involved the ventral part of the Gi. d A C6 section showing the labeled fibers in both the ventral and lateral funiculi (red arrows). Note the ipsilateral predominance, especially in the ventral funiculus (the right is the ipsilateral side and the left is the contralateral side). e A C6 section showing labeled fibers in both the ventral and lateral funiculi (red arrows) and in lamina 6–10 on the ipsilateral side. f A higher magnification of the rectangular area in e. Note densely labeled fibers in medial laminae 7 and 8, and 9, and 10. g A C6 section showing labeled fibers in both the ventral and lateral funiculi (red arrows) and lamina 6–10 on the contralateral side. h A higher magnification of the rectangular area in g. Note labeled fibers in medial laminae 5–7 and 10. i A T9 section showing labeled fibers in both the lateral and ventral funiculi and in laminae 5, 7–10 (red arrows). Note the density of labeled fibers in the ventral funiculus is higher than that of the lateral funiculus. j An L5 section showing labeled fibers in both the ventral and lateral funiculi (red arrows). Note the similar density of labeled fibers in the ventral and lateral funiculi. k An L5 section showing labeled fibers in the ipsilateral dorsal horn (the top right rectangular area in j). Note labeled fibers in laminae 3–6, and to a lesser extent in laminae 1–3. l An L5 section showing labeled fibers in the ipsilateral ventral horn (the lower right rectangular area in j). Note more labeled fibers in laminae 8 and 9 than those from raphe nuclei. m An L5 section showing labeled fibers in the contralateral dorsal horn (the top left rectangular area in j). Note labeled fibers in laminae 4–6, and to a lesser extent in lamina 3. n An L5 section showing labeled fibers in the contralateral ventral horn (the lower left rectangular area in j). Note labeled fibers in laminae 7–9. o An S2 section showing labeled fibers in the lateral and ventral funiculi and in all laminae except in the ipsilateral laminae 1–3. Note the density of labeled fibers in the lateral funiculus is higher than that in the ventral funiculus. The scale bar 500 μm in ac, 400 μm in d, 300 μm in i, j, and o, 200 μm in e, g, k, and m, 100 μm in f, h, l, n, and the microphotograph in b.

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