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Figure 4 | Molecular Pain

Figure 4

From: Distribution of raphespinal fibers in the mouse spinal cord

Figure 4

Termination pattern of BDA labeled fibers arising from the rostral part of GiA. ac An injection site in GiA, which involved the medial portion of the caudal part of the pontine reticular nucleus (red dashed circle). d A C5 section showing the labelled fibers in both the ventral and lateral funiculi (red arrows) on both sides with an ipsilateral predominance (the right is the ipsilateral side and the left is the contralateral side). e A higher magnification of the dorsal rectangular area in d showing labeled fibers in laminae 1–6 with a low density of fibers in lamina 3 on the ipsilateral side (red arrows). f A higher magnification of the ventral rectangular area in d showing densely labeled fibers in laminae 8, 10, and the medial part of laminae 7, 9 on the ipsilateral side (red arrows). g A T5 section showing labeled fibers in both the ventral and lateral funiculi (red arrows). Note the density of labeled fibers in the dorsolateral funiculus is higher than that in the cervical cord. h A higher magnification of the dorsal rectangular area in g showing labeled fibers in laminae 1–7, and 10 with a low density of fibers in lamina 3 on the contralateral side (red arrows). i A higher magnification of the ventral rectangular area in g showing densely labeled fibers in laminae 7–10 with an ipsilateral predominance (red arrows). j An L5 section showing labeled fibers in the lateral and ventral funiculi and in all laminae of the gray matter. Note there are more fibers in the lateral funiculus than in the ventral funiculus. k A higher magnification of the left rectangular area in j showing labeled fibers in laminae 7–10 with more fibers in the lateral lamina 9 (red arrows). l A higher magnification of the right rectangular area in j showing densely labeled fibers in laminae 7, 8, 10, and the medial lamina 9 with few fibers in the lateral lamina 9 (red arrows). The scale bar 500 μm in ac, 400 μm in d and j, 300 μm in g, 100 μm in e, f, h, i, k, l, and the microphotograph in c.

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