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Fig. 3 | Molecular Pain

Fig. 3

From: Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors

Fig. 3

Effects of maprotiline on the antinociceptive effect of morphine under the UCMS condition. The effects of maprotiline on the thermal pain sensitivity (a) and the antinociceptive effect of morphine (3 mg/kg; b) in a hot-plate test under the UCMS (white column vehicle, n = 12; gray column maprotiline 3 mg/kg, n = 12; black column maprotiline 10 mg/kg, n = 14) and non-stress (white column vehicle, n = 14; gray column maprotiline 3 mg/kg, n = 12; black column maprotiline 10 mg/kg, n = 14) conditions. * p < 0.05, significantly differed from vehicle-injected UCMS mice. Data are expressed as mean ± SEM.

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Molecular Pain

ISSN: 1744-8069

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