Fig. 2
Changes in NF200-IR fibre innervation in the upper dermis of the paw skin of cuff and SNI rats. Photomicrographs show representative examples of NF200-IR fibre innervation (red) in the plantar paw skin of sham animals (a), and 2 (b), 6 (c) and 16 weeks (d) after cuff. Representative images of NF200-IR innervation in the plantar paw skin of sham animals (f) and 2 (g), 6 (h) and 16 (i) weeks after SNI. Representative images of NF200-IR innervation in the lateral paw skin of sham animals (k) and 2 (l), 6 (m) and 16 (n) weeks after SNI. Bar graphs show average NF200-IR fibre length (µm) per unit area of upper dermis (µm2) in the plantar paw skin at various times after cuff (e) and SNI (j) and in the lateral paw skin after SNI (o). Each point represents the mean ± SEM (n = 4–6 per group); *p < 0.05, ***p < 0.001 by one way ANOVA with Dunnett’s post hoc; scale bar 50 µm