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Fig. 4 | Molecular Pain

Fig. 4

From: Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain

Fig. 4

Changes in DBH-IR sympathetic fibre innervation in the upper dermis of the paw skin of cuff and SNI rats. Photomicrographs show representative examples of DBH-IR fibre innervation (red) in the plantar paw skin of sham animals and 2, 6 weeks after cuff (ac) or SNI (df). Bar graphs show average number of ectopic DBH-IR fibres in the upper dermis of the plantar paw skin of cuff (g) and SNI rats (h) and in the lateral paw skin of SNI animals (i) at various times after injury. The values reported are per 1 mm2 of upper dermis. Each point represents the mean ± SEM (n = 4–6 per group); *p < 0.05, ***p < 0.001 by one way ANOVA with Dunnett’s post hoc; scale bar 50 µm

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