Fig. 2
Main steps that regulates the subcellular distribution of Navs in primary sensory neurons. The surface expression of Navs is achieved by escape from the endoplasmic reticulum and proteasome degradation, forward trafficking and plasma membrane anchoring in primary sensory neurons. Axonal transport and localization of Navs in afferent fibers involves motor proteins and scaffold proteins. Localization of Nav1.6 to the nodes of Ranvier in myelinated fibers of primary sensory neurons requires node formation and the submembrane cytoskeletal protein complex. The molecules listed are mostly positive regulators except NEDD4-2 that may impede forward trafficking of Nav1.7. However, the hypothesized roles of molecules with question mark during various steps of Nav trafficking in primary sensory neuron need to be proved