MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences

Table 2 microRNA in whole blood circulating in the early aftermath of motor vehicle collision in African Americans that predict axial pain development 6 weeks after MVC trauma

microRNA	Mean fold difference^a	p value^b	Previous assoc^c
miR-135a-5p	2.49	3 × 10 ⁻⁴	S, N [47, 48]
miR-3613-3p	2.02	0.001
miR-19b-3p	1.67	0.004	S, P [49, 51]
miR-502-3p	1.75	0.004
miR-500a-3p	1.39	0.005
miR-1296-5p	1.99	0.006	S [50]
miR-454-5p	1.58	0.010
miR-99a-5p	1.48	0.010	P [71]
miR-501-5p	−1.15	0.011
miR-362-5p	1.41	0.013
miR-154-5p	1.09	0.015
Let-7a-3p	1.48	0.020	S, P [50, 72]
miR-185-5p	−3.45	0.021	P [52]
miR-339-5p	1.31	0.023
miR-29c-5p	1.67	0.023
miR-4659b-3p	−2.19	0.023
miR-15b-5p	−1.22	0.026
miR-329-3p	1.68	0.026
miR-20b-5p	1.35	0.029	S [73]
miR-500b-5p	1.38	0.029
Let-7f-2-3p	1.43	0.029
miR-7-5p	−2.12	0.033	P [53, 73]
miR-378a	1.37	0.034
miR-3130-5p	1.91	0.034
miR-532-5p	1.31	0.036
miR-345-5p	1.62	0.037
miR-16-5p	−2.70	0.043
miR-18a-3p	1.49	0.044
miR-337-3p	−1.06	0.045
miR-26b-3p	−3.71	0.046	P [54]
miR-26a-5p	−2.52	0.048
miR-151b	1.33	0.048

^aMean fold difference was calculated by dividing the average sequencing read counts for individuals developing axial pain by the average sequencing read counts for individuals who recover
^bp values were calculated using the Mann–Whitney U test. Italicized miRNA remained significant after correcting for multiple testing (FDR = 0.15)
^cPrevious assoc = references describing a previously identified role for the miRNA in stress system biology (S), pain pathobiology (P), or neuropsychiatric disease (N)

ISSN: 1744-8069