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Fig. 5 | Molecular Pain

Fig. 5

From: Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to acute cold hypersensitivity after oxaliplatin administration

Fig. 5

Oxaliplatin increases TRPA1 protein expression as seen with immunohistochemistry in the DRG. a Effect of oxaliplatin (6 mg/kg, i.p.) on co-localization of TRPA1 protein expression with isolectin B4 binding in rat DRG (L4–6) neurons. The photomicrographs show representative data. Co-localization of TRPA1 expression (red) and isolectin B4 binding (green) is shown. Double-labeled neurons (arrowheads) are stained yellow in the merged panel. b Histogram shows the percent of TRPA1-positive neurons relative to isolectin B4-binding neurons. TRPA1 and isolectin B4 co-localization was significantly higher on day 2 after oxaliplatin administration (6 mg/kg, i.p.) compared to 5 % glucose treatment. Data are the mean ± SEM. n = 4 each for 5 % glucose and oxaliplatin administration (6 mg/kg, i.p.). *P < 0.05 versus 5 % glucose

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Molecular Pain

ISSN: 1744-8069

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