Age-dependent sensitization of cutaneous nociceptors during developmental inflammation

Molecular Pain

Table 3 Percent changes in mRNA expression in the L2/L3 DRGs after inflammation

Gene	P7 Inflammation (1d)	P7 Inflammation (3d)	P14 Inflammation (1d)	P14 Inflammation (3d)
trkA	-46 ± 22^#	-99 ± 30*	-46 ± 17	-92 ± 20*
GFRα1	-29 ± 27	-69 ± 35*	-1 ± 9	18 ± 10
GFRα3	-47 ± 17*	-99 ± 9*	-32 ± 12	-91 ± 11*
IGFr1	98 ± 36*	754 ± 34*	169 ± 19*	831 ± 31*
IL1r1	257 ± 31*	268 ± 15*	50 ± 22	387 ± 12*
ASIC1	18 ± 25	-15 ± 31	-18 ± 45	-11 ± 9
ASIC3	115 ± 24*	16 ± 34	-19 ± 60	-28 ± 7
TRPA1	143 ± 37*	-38 ± 14	83 ± 29*	-7 ± 12
TRPC3	-25 ± 23	-30 ± 7	84 ± 29*	-57 ± 39
TRPM3	52 ± 11*	-30 ± 20	4 ± 18	-36 ± 22
TRPM6	174 ± 33*	-20 ± 22	159 ± 29*	-47 ± 51
TRPV1	1 ± 28	52 ± 35	69 ± 10*	10 ± 76
P2Y1	107 ± 22*	-23 ± 20	-31 ± 27	-50 ± 40
P2X3	-16 ± 15	40 ± 26	29 ± 15	21 ± 5
Piezo2	-14 ± 18	60 ± 20	58 ± 11*	87 ± 9*

Data presented are percent changes in expression from DRGs with cutaneous inflammation induced at P7 or P14 by hairy skin injection of carrageenan compared to age-matched naives. *p value < 0.05; #p value < 0.1. Mean ± SEM; One-way ANOVA with Tukey’s post hoc test.

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